ChloroquineV1, Main, Exploration, bibRecord, 001282

Discordant temporal evolution of Pfcrt and Pfmdr1 genotypes and Plasmodium falciparum in vitro drug susceptibility to 4-aminoquinolines after drug policy change in French Guiana.

Identifieur interne : 001282 ( Main/Exploration ); précédent : 001281; suivant : 001283

Discordant temporal evolution of Pfcrt and Pfmdr1 genotypes and Plasmodium falciparum in vitro drug susceptibility to 4-aminoquinolines after drug policy change in French Guiana.

Auteurs : Eric Legrand ; Joséphine Yrinesi ; Marie-Thérèse Ekala [France] ; Julie Péneau ; Béatrice Volney ; Franck Berger ; Christiane Bouchier [France] ; Stéphane Bertani ; Lise Musset ; Jean-Baptiste Meynard ; Odile Mercereau-Puijalon [France]

Source :

Antimicrobial Agents and Chemotherapy [ 0066-4804 ] ; 2012-03.

RBID : Hal:pasteur-00705562

Abstract

Analysis of the evolution of drug target genes under changing drug policy is needed to assist monitoring of Plasmodium falciparum drug resistance in the field. Here we genotype Pfcrt and Pfdmr1 of 700 isolates collected in French Guiana from 2000 (5 years after withdrawal of chloroquine) to 2008, i.e., the period when the artemether-lumefantrine combination was progressively introduced and mefloquine was abandoned. Gene sequencing showed fixation of the 7G8-type Pfcrt SMVNT resistance haplotype and near fixation of the NYCDY Pfdmr1 haplotype. Pfdmr1 gene copy number correlated with 50% inhibitory concentrations of mefloquine and halofantrine (r = 0.64 and 0.47, respectively, n = 547); its temporal changes paralleled changes in in vitro mefloquine susceptibility. However, the molecular parameters studied did not account for the regained in vitro susceptibility to chloroquine and showed a poor correlation with susceptibility to artemether, lumefantrine, or quinine. Identification of novel markers of resistance to these antimalarials is needed in this South American area.

Url:

https://hal-riip.archives-ouvertes.fr/pasteur-00705562

DOI: 10.1128/AAC.05280-11

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000072
to stream Hal, to step Curation: 000072
to stream Hal, to step Checkpoint: 000152
to stream Main, to step Merge: 001283
to stream Main, to step Curation: 001282

Le document en format XML

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<author><name sortKey="Volney, Beatrice" sort="Volney, Beatrice" uniqKey="Volney B" first="Béatrice" last="Volney">Béatrice Volney</name>
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          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
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<author><name sortKey="Berger, Franck" sort="Berger, Franck" uniqKey="Berger F" first="Franck" last="Berger">Franck Berger</name>
<affiliation><hal:affiliation type="institution" xml:id="struct-300193" status="VALID">          <orgName>Institut Pasteur de la Guyane</orgName>
          <desc>            <address>              <addrLine>23 Avenue Pasteur BP 6010 - 97306 Cayenne Cedex </addrLine>
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          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
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            <ref type="url">https://research.pasteur.fr/ip-network</ref>
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<wicri:noCountry>GF</wicri:noCountry>
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<author><name sortKey="Bouchier, Christiane" sort="Bouchier, Christiane" uniqKey="Bouchier C" first="Christiane" last="Bouchier">Christiane Bouchier</name>
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          <idno type="ISNI">0000 0001 2353 6535</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <date type="start">1887-06-04</date>
          <desc>            <address>              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Bertani, Stephane" sort="Bertani, Stephane" uniqKey="Bertani S" first="Stéphane" last="Bertani">Stéphane Bertani</name>
<affiliation><hal:affiliation type="institution" xml:id="struct-300193" status="VALID">          <orgName>Institut Pasteur de la Guyane</orgName>
          <desc>            <address>              <addrLine>23 Avenue Pasteur BP 6010 - 97306 Cayenne Cedex </addrLine>
              <country key="GF"></country>
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          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
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            <ref type="url">https://research.pasteur.fr/ip-network</ref>
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<author><name sortKey="Musset, Lise" sort="Musset, Lise" uniqKey="Musset L" first="Lise" last="Musset">Lise Musset</name>
<affiliation><hal:affiliation type="institution" xml:id="struct-300193" status="VALID">          <orgName>Institut Pasteur de la Guyane</orgName>
          <desc>            <address>              <addrLine>23 Avenue Pasteur BP 6010 - 97306 Cayenne Cedex </addrLine>
              <country key="GF"></country>
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          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://research.pasteur.fr/ip-network</ref>
          </desc>
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</tutelle>
</tutelles>
</hal:affiliation>
<wicri:noCountry>GF</wicri:noCountry>
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</author>
<author><name sortKey="Meynard, Jean Baptiste" sort="Meynard, Jean Baptiste" uniqKey="Meynard J" first="Jean-Baptiste" last="Meynard">Jean-Baptiste Meynard</name>
<affiliation><hal:affiliation type="institution" xml:id="struct-300193" status="VALID">          <orgName>Institut Pasteur de la Guyane</orgName>
          <desc>            <address>              <addrLine>23 Avenue Pasteur BP 6010 - 97306 Cayenne Cedex </addrLine>
              <country key="GF"></country>
            </address>
            <ref type="url">http://www.pasteur-cayenne.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-301247" type="direct"></relation>
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        <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID">          <orgName>Réseau International des Instituts Pasteur</orgName>
          <orgName type="acronym">RIIP</orgName>
          <desc>            <address>              <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://research.pasteur.fr/ip-network</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<wicri:noCountry>GF</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mercereau Puijalon, Odile" sort="Mercereau Puijalon, Odile" uniqKey="Mercereau Puijalon O" first="Odile" last="Mercereau-Puijalon">Odile Mercereau-Puijalon</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-28152" status="OLD">          <orgName>Immunologie moléculaire des parasites</orgName>
          <desc>            <address>              <addrLine>25-28 rue du Docteur Roux F-75724 Paris Cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.pasteur.fr/</ref>
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          <idno type="ISNI">0000 0001 2353 6535</idno>
          <orgName>Institut Pasteur [Paris]</orgName>
          <date type="start">1887-06-04</date>
          <desc>            <address>              <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">https://www.pasteur.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR2581" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1128/AAC.05280-11</idno>
<series><title level="j">Antimicrobial Agents and Chemotherapy</title>
<idno type="ISSN">0066-4804</idno>
<imprint><date type="datePub">2012-03</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en">              <p>Analysis of the evolution of drug target genes under changing drug policy is needed to assist monitoring of Plasmodium falciparum drug resistance in the field. Here we genotype Pfcrt and Pfdmr1 of 700 isolates collected in French Guiana from 2000 (5 years after withdrawal of chloroquine) to 2008, i.e., the period when the artemether-lumefantrine combination was progressively introduced and mefloquine was abandoned. Gene sequencing showed fixation of the 7G8-type Pfcrt SMVNT resistance haplotype and near fixation of the NYCDY Pfdmr1 haplotype. Pfdmr1 gene copy number correlated with 50% inhibitory concentrations of mefloquine and halofantrine (r = 0.64 and 0.47, respectively, n = 547); its temporal changes paralleled changes in in vitro mefloquine susceptibility. However, the molecular parameters studied did not account for the regained in vitro susceptibility to chloroquine and showed a poor correlation with susceptibility to artemether, lumefantrine, or quinine. Identification of novel markers of resistance to these antimalarials is needed in this South American area.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><noCountry><name sortKey="Berger, Franck" sort="Berger, Franck" uniqKey="Berger F" first="Franck" last="Berger">Franck Berger</name>
<name sortKey="Bertani, Stephane" sort="Bertani, Stephane" uniqKey="Bertani S" first="Stéphane" last="Bertani">Stéphane Bertani</name>
<name sortKey="Legrand, Eric" sort="Legrand, Eric" uniqKey="Legrand E" first="Eric" last="Legrand">Eric Legrand</name>
<name sortKey="Meynard, Jean Baptiste" sort="Meynard, Jean Baptiste" uniqKey="Meynard J" first="Jean-Baptiste" last="Meynard">Jean-Baptiste Meynard</name>
<name sortKey="Musset, Lise" sort="Musset, Lise" uniqKey="Musset L" first="Lise" last="Musset">Lise Musset</name>
<name sortKey="Peneau, Julie" sort="Peneau, Julie" uniqKey="Peneau J" first="Julie" last="Péneau">Julie Péneau</name>
<name sortKey="Volney, Beatrice" sort="Volney, Beatrice" uniqKey="Volney B" first="Béatrice" last="Volney">Béatrice Volney</name>
<name sortKey="Yrinesi, Josephine" sort="Yrinesi, Josephine" uniqKey="Yrinesi J" first="Joséphine" last="Yrinesi">Joséphine Yrinesi</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Ekala, Marie Therese" sort="Ekala, Marie Therese" uniqKey="Ekala M" first="Marie-Thérèse" last="Ekala">Marie-Thérèse Ekala</name>
</noRegion>
<name sortKey="Bouchier, Christiane" sort="Bouchier, Christiane" uniqKey="Bouchier C" first="Christiane" last="Bouchier">Christiane Bouchier</name>
<name sortKey="Mercereau Puijalon, Odile" sort="Mercereau Puijalon, Odile" uniqKey="Mercereau Puijalon O" first="Odile" last="Mercereau-Puijalon">Odile Mercereau-Puijalon</name>
</country>
</tree>
</affiliations>
</record>

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Discordant temporal evolution of Pfcrt and Pfmdr1 genotypes and Plasmodium falciparum in vitro drug susceptibility to 4-aminoquinolines after drug policy change in French Guiana.

Discordant temporal evolution of Pfcrt and Pfmdr1 genotypes and Plasmodium falciparum in vitro drug susceptibility to 4-aminoquinolines after drug policy change in French Guiana.

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